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p53 is frequently mutated in Burkitt's lymphoma cell lines.
Ludwig Institute for Cancer Research, St Mary's Hospital Medical School, London, UK.
A panel of 12 Burkitt's lymphoma cell lines and four other B cell lines were tested for the presence of mutations in p53. Protein analysis using a mutant-specific antibody and sequencing of both cDNA and genomic DNA revealed changes relative to the standard p53 protein sequence in 12 of the 16 lines studied, including 10 of the BL lines. Mutation of p53 in the BL lines was usually accompanied by loss of the other allele of p53. Testing of the mutated p53 cDNAs for gain of transforming activity or loss of growth suppression activity showed that several of the BL mutants were functionally altered from wild-type p53.
PMID: 1915267 [PubMed - indexed for MEDLINE]
PMCID: PMC452998
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Cited by 31 PubMed Central articles
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Non-conservative homologous recombination in human B lymphocytes is promoted by activation-induced cytidine deaminase and transcription.
Mierau M, Drexler GA, Kutzera A, Braunschmidt K, Ellwart J, Eckardt-Schupp F, Fritz E, Bachl J, Jungnickel B.
Nucleic Acids Res. 2008 Oct; 36(17):5591-601. Epub 2008 Aug 30.
[Nucleic Acids Res. 2008]
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Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors.
Dreyfus DH, Nagasawa M, Gelfand EW, Ghoda LY.
BMC Immunol. 2005 Jun 21; 6:12. Epub 2005 Jun 21.
[BMC Immunol. 2005]
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Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes.
Machida K, Cheng KT, Sung VM, Lee KJ, Levine AM, Lai MM.
J Virol. 2004 Aug; 78(16):8835-43.
[J Virol. 2004]
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