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Human D-type cyclin.
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724.
A cDNA library prepared from a human glioblastoma cell line has been introduced into a budding yeast strain that lacks CLN1 and CLN2 and is conditionally deficient for CLN3 function. We rescued a gene that we call cyclin D1. It is related to A-, B-, and CLN-type cyclins, but appears to define a new subclass within the cyclin gene family. Transcription of the cyclin D1 gene gives rise to two major transcripts through alternative polyadenylation. The cyclin D1 gene transcript and its 34 kd product are both abundant in the glioblastoma cell line of origin.
PMID: 1827756 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
Li Q, Yang Z.
J Exp Clin Cancer Res. 2009 May 18; 28:65. Epub 2009 May 18.
[J Exp Clin Cancer Res. 2009]
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Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms.
Liu R, Wang L, Chen C, Liu Y, Zhou P, Wang Y, Wang X, Turnbull J, Minassian BA, Liu Y, et al.
Mol Cell Biol. 2008 Dec; 28(23):7236-44. Epub 2008 Sep 29.
[Mol Cell Biol. 2008]
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ReviewP21 and p27: roles in carcinogenesis and drug resistance.
Abukhdeir AM, Park BH.
Expert Rev Mol Med. 2008 Jul 1; 10:e19. Epub 2008 Jul 1.
[Expert Rev Mol Med. 2008]
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