Crystal structure of a biosynthetic sulfo-hirudin ...[J Am Chem Soc. 2007]

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1: J Am Chem Soc. 2007 Sep 5;129(35):10648-9. Epub 2007 Aug 9. Links

Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

Liu CC, Brustad E, Liu W, Schultz PG.

Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

PMID: 17685615 [PubMed - indexed for MEDLINE]

PMCID: PMC2530905

pH dependence of the interaction of hirudin with thrombin.
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» See reviews... | » See all...

Cited by 2 PubMed Central articles

Protein evolution with an expanded genetic code.
Liu CC, Mack AV, Tsao ML, Mills JH, Lee HS, Choe H, Farzan M, Schultz PG, Smider VV. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17688-93. Epub 2008 Nov 11.

[Proc Natl Acad Sci U S A. 2008]
An engineered protease that cleaves specifically after sulfated tyrosine.
Varadarajan N, Georgiou G, Iverson BL. Angew Chem Int Ed Engl. 2008; 47(41):7861-3.

[Angew Chem Int Ed Engl. 2008]

Structures reported by this article

Crystal Structure Of Sulfo-Hirudin Complexed To Thrombin

PDB: 2PW8

Source: Homo sapiens, Hirudo medicinalis

Method: X-Ray Diffraction | Resolution: 1.84 Å

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Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

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Cited by 2 PubMed Central articles

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