The amyloid beta protein precursor or proteinase n...[Biochim Biophys Acta. 1991]

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1: Biochim Biophys Acta. 1991 Dec 2;1129(1):141-3. Links

The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported.

De Strooper B, Van Leuven F, Van den Berghe H.

Center for Human Genetics, University of Leuven, Belgium.

The cDNA sequence for amyloid precursor protein and the two alternatively spliced forms were determined. Seven nucleotide differences resulting in six amino acid differences compared to the previously published mouse sequence were found. Moreover, the 3' non-coding end was completely different. Part of these findings were confirmed in three different mouse strains. The resulting mouse cDNA resembles the human APP more closely than originally reported.

PMID: 1756177 [PubMed - indexed for MEDLINE]

Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8).
Biochem Cell Biol. 2001; 79(1):57-67.

[Biochem Cell Biol. 2001]
Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins.
J Biol Chem. 1994 May 13; 269(19):14227-34.

[J Biol Chem. 1994]
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.
Am J Pathol. 1991 Jun; 138(6):1423-35.

[Am J Pathol. 1991]
Analysis of mouse intron 7 DNA sequence of the APP gene: comparison with the human homologue.
DNA Seq. 1999; 10(4-5):219-28.

[DNA Seq. 1999]
ReviewThe amyloid peptide precursor in Alzheimer's disease.
Acta Neurol Belg. 1995 Dec; 95(4):197-209.

[Acta Neurol Belg. 1995]
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Cited by 3 PubMed Central articles

Introduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: a comparison of homologous recombination methods.
Gschwind M, Huber G. Mol Cell Biol. 1998 Aug; 18(8):4651-8.

[Mol Cell Biol. 1998]
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. J Cell Biol. 1993 Apr; 121(2):295-304.

[J Cell Biol. 1993]
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. EMBO J. 1995 Oct 16; 14(20):4932-8.

[EMBO J. 1995]

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The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported.

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Cited by 3 PubMed Central articles

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