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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
Osaka Bioscience Institute, Japan.
Mouse anti-Fas monoclonal antibody has a cytolytic activity on human cells that express the antigen. Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells. The nucleotide sequence of the cDNAs revealed that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide (Mr 36,000) with a single transmembrane domain. The extracellular domain is rich in cysteine residue, and shows a similarity to that of human tumor necrosis factor receptors, human nerve growth factor receptor, and human B cell antigen CD40. Murine WR19L cells or L929 cells transformed with the human Fas antigen cDNA were killed by the anti-Fas antibody in the process known as apoptosis.
PMID: 1713127 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Highly parallel identification of essential genes in cancer cells.
Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, et al.
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[Proc Natl Acad Sci U S A. 2008]
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Ulett GC, Adderson EE.
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[Curr Immunol Rev. 2006]
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Olsen RJ, Tarantolo SR, Hinrichs SH.
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[Sarcoma. 2002]
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