Your browser version may not work well with NCBI's Web applications. More information here...
1: Science. 1991 May 10;252(5007):839-42.Click here to read Links

Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.

Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J.

Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301.

The structure of the human FK506 binding protein (FKBP), complexed with the immunosuppressant FK506, has been determined to 1.7 angstroms resolution by x-ray crystallography. The conformation of the protein changes little upon complexation, but the conformation of FK506 is markedly different in the bound and unbound forms. The drug's association with the protein involves five hydrogen bonds, a hydrophobic binding pocket lined with conserved aromatic residues, and an unusual carbonyl binding pocket. The nature of this complex has implications for the mechanism of rotamase catalysis and for the biological actions of FK506 and rapamycin.

PMID: 1709302 [PubMed - indexed for MEDLINE]

Structures reported by this article

Patient Drug Information

  • Tacrolimus (Prograf® )

    Tacrolimus is used along with other medications to prevent rejection (attack of a transplanted organ by the immune system of a person receiving the organ) in people who have received kidney, liver, or heart transplants. ...

  • Source: AHFS Consumer Medication Information