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Thymic tumorigenesis induced by overexpression of p56lck.
Howard Hughes Medical Institute, University of Washington, Seattle 98195.
The lck gene encodes a membrane-associated protein tyrosine kinase (p56lck) that is believed to participate in lymphocyte-specific signal transduction pathways. To investigate the function of this molecule, transgenic mice were generated carrying the wild-type lck gene or a mutated lck gene encoding a constitutively activated form of p56lck (p56lckF505). Transgene expression in thymocytes was achieved in each case using the lck proximal promoter element. Mice expressing high levels of either p56lckF505 or p56lckY505 reproducibly developed thymic tumors. The sensitivity of thymocytes to p56lck-induced transformation suggests that disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases.
PMID: 1708890 [PubMed - indexed for MEDLINE]
PMCID: PMC51576
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Cited by 32 PubMed Central articles
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A mechanism misregulating p27 in tumors discovered in a functional genomic screen.
Garrett-Engele CM, Tasch MA, Hwang HC, Fero ML, Perlmutter RM, Clurman BE, Roberts JM.
PLoS Genet. 2007 Dec; 3(12):e219.
[PLoS Genet. 2007]
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The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function.
Dobenecker MW, Schmedt C, Okada M, Tarakhovsky A.
Mol Cell Biol. 2005 Dec; 25(23):10533-42.
[Mol Cell Biol. 2005]
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Regulation of the Src family kinase Lck by Hsp90 and ubiquitination.
Giannini A, Bijlmakers MJ.
Mol Cell Biol. 2004 Jul; 24(13):5667-76.
[Mol Cell Biol. 2004]
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