Your browser version may not work well with NCBI's Web applications. More information here...
1: FEBS Lett. 1990 Oct 29;273(1-2):215-8.Links

A mitochondrial protein fraction catalyzing transport of the K+ analog T1+.

Diwan JJ, Paliwal R, Kaftan E, Bawa R.

Biology Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590.

A protein fraction has been obtained from detergent-solubilized mitochondrial membranes by its affinity for quinine, an inhibitor of K+ transport. A peptide derived from the predominant 53 kDa protein in this fraction is found to be identical in sequence to a portion of aldehyde dehydrogenase. Antigenically unrelated bands at 97, 77, 57, and 31 kDa are also seen on polyacrylamide gels. Observations utilizing a fluorescent probe entrapped in the lumen of membrane vesicles indicate that the reconstituted protein fraction imparts permeability to the K+ analog Tl+. These and other findings suggest that the affinity purified fraction includes a cation transport catalyst.

PMID: 1699808 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Potassium (Glu-K® , K+ 10® , K+ 8® , ...)

    Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...

  • Quinine (Qualaquin® )

    Quinine is used alone or with other medications to treat malaria (a serious or life-threatening illness that is spread by mosquitos in certain parts of the world). Quinine should not be used to prevent malaria or to prev...

  • Source: AHFS Consumer Medication Information