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Expression of a novel transcript of the myelin basic protein gene.
Mental Retardation Research Center, UCLA Medical School 90024.
A cDNA (M41) corresponding to a mouse myelin basic protein (MBP) mRNA with a longer 5'-untranslated region than predicted from earlier studies of MBP gene structure has been isolated and characterized. The additional 5'-untranslated region is encoded by two previously unidentified exons upstream of the major transcription start site of the gene. Using a DNA probe specific for M41-MBP mRNAs, Northern blot analysis indicated that expression of this transcript follows a developmental course in mouse brain similar to that of the majority of MBP mRNAs, but that the level of expression varies between brain and spinal cored. Expression of MBP mRNAs similar to the mouse M41-MBP also was identified in rat brain. The results suggest that the structure of the MBP gene is more complex than originally thought, containing at least two more exons. There appears to be at least one more MBP gene promoter that directs the synthesis of a subset of MBP mRNAs with a unique 5'-untranslated region.
PMID: 1692584 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Unique clinical and pathological features in HLA-DRB1*0401-restricted MBP 111-129-specific humanized TCR transgenic mice.
Quandt JA, Baig M, Yao K, Kawamura K, Huh J, Ludwin SK, Bian HJ, Bryant M, Quigley L, Nagy ZA, et al.
J Exp Med. 2004 Jul 19; 200(2):223-34.
[J Exp Med. 2004]
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Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice.
Polanczyk M, Yellayi S, Zamora A, Subramanian S, Tovey M, Vandenbark AA, Offner H, Zachary JF, Fillmore PD, Blankenhorn EP, et al.
Am J Pathol. 2004 Jun; 164(6):1915-24.
[Am J Pathol. 2004]
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The shiverer mutation affects the persistence of Theiler's virus in the central nervous system.
Bihl F, Pena-Rossi C, Guénet JL, Brahic M, Bureau JF.
J Virol. 1997 Jul; 71(7):5025-30.
[J Virol. 1997]
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