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1: J Virol. 2006 Apr;80(8):4191-5.Click here to read Click here to read Links

Cellular factors required for Lassa virus budding.

Urata S, Noda T, Kawaoka Y, Yokosawa H, Yasuda J.

First Department of Forensic Science, National Research Institute of Police Science, Kashiwa 277-0882, Japan.

It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally. Our data may provide a clue to develop an effective antiviral strategy for Lassa virus.

PMID: 16571837 [PubMed - indexed for MEDLINE]

PMCID: PMC1440458