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LRRK2 expression linked to dopamine-innervated areas.
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
OBJECTIVE: Leucine-rich repeat kinase 2 (LRRK2) has been linked to Parkinson's disease. Our study explores the expression of LRRK2 in human and rodent brain tissue. METHODS: We analyzed LRRK2 gene activity at the cellular level using in situ hybridization. RESULTS: We found a high and strikingly specific expression of LRRK2 mRNA in rodent striatum and parts of cortex and no signals in dopamine neurons. In human tissue, LRRK2 mRNA was found in the corresponding brain areas caudatus and putamen at lower levels and dopamine neurons were also devoid of LRRK2 mRNA. Expression levels in striatal tissue did not differ between Parkinson's disease patients and control subjects. INTERPRETATION: Unlike all other genes so far linked to Parkinson's disease, our results demonstrate that LRRK2 expression is particularly high in brain dopaminoceptive areas.
PMID: 16532471 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation.
Milosevic J, Schwarz SC, Ogunlade V, Meyer AK, Storch A, Schwarz J.
Mol Neurodegener. 2009 Jun 15; 4:25. Epub 2009 Jun 15.
[Mol Neurodegener. 2009]
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Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle.
Malkus KA, Tsika E, Ischiropoulos H.
Mol Neurodegener. 2009 Jun 5; 4:24. Epub 2009 Jun 5.
[Mol Neurodegener. 2009]
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Update on the functional biology of Lrrk2.
Melrose H.
Future Neurol. 2008; 3(6):669-681.
[Future Neurol. 2008]
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