-
The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions.
Developmental Biology Center, University of California, Irvine 92717.
Mutations of the lethal(1)discs large-1 (dlg) tumor suppressor gene of Drosophila cause neoplastic overgrowth of the imaginal discs. Sequencing of a near full-length cDNA predicts a protein containing a domain homologous to yeast guanylate kinase and a region homologous to SH3, a putative regulatory motif in nonreceptor protein tyrosine kinases and other signal transduction proteins. Immunofluorescence analysis using antibodies directed against fusion peptides shows that the dlg gene product is localized in an apical belt of the lateral cell membrane, at the position of the septate junction. The results suggest that a signal transduction process involving guanine nucleotides occurs at the septate junction and is necessary for cell proliferation control in Drosophila epithelia.
PMID: 1651169 [PubMed - indexed for MEDLINE]
-
Cited by 85 PubMed Central articles
-
Roles of transient receptor potential channels in pain.
Stucky CL, Dubin AE, Jeske NA, Malin SA, McKemy DD, Story GM.
Brain Res Rev. 2009 Apr; 60(1):2-23. Epub 2008 Dec 31.
[Brain Res Rev. 2009]
-
Differential regulation of Dlg1, Scrib, and Lgl1 expression in a transgenic mouse model of ocular cancer.
Vieira V, de la Houssaye G, Lacassagne E, Dufier JL, Jaïs JP, Beermann F, Menasche M, Abitbol M.
Mol Vis. 2008; 14:2390-403. Epub 2008 Dec 19.
[Mol Vis. 2008]
-
The Drosophila STIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning.
Eid JP, Arias AM, Robertson H, Hime GR, Dziadek M.
BMC Dev Biol. 2008 Oct 24; 8:104. Epub 2008 Oct 24.
[BMC Dev Biol. 2008]
- » See all...