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1: Plant Cell Rep. 2006 Jun;25(6):540-5. Epub 2006 Jan 12.Click here to read Links

A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis.

Kono A, Ohno R, Umeda-Hara C, Uchimiya H, Umeda M.

Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1-1-1, Tokyo 113-0032, Japan.

The Arabidopsis genome encodes 10 D-type cyclins (CYCD); however, their differential role in cell cycle control is not well known. Among them, CYCD4;2 is unique in the amino acid sequence; namely, it lacks the Rb-binding motif and the PEST sequence that are conserved in CYCDs. Here, we have shown that CYCD4;2 suppressed G1 cyclin mutations in yeast and formed a kinase complex with CDKA;1, an ortholog of yeast Cdc28, in insect cells. Hypocotyl explants of CYCD4;2 over-expressing plants showed faster induction of calli than wild-type explants on a medium containing lower concentration of auxin. These results suggest that CYCD4;2 has a promotive function in cell division by interacting with CDKA;1 regardless of the unusual primary sequence.

PMID: 16408177 [PubMed - indexed for MEDLINE]