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Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus.
Laboratoire de mycologie, Centre hospitalier universitaire vaudois, Lausanne, Switzerland.
An Aspergillus fumigatus extracellular alkaline protease (ALP) which is an enzyme of the subtilisin family is a potential virulent factor of the fungus. The gene encoding ALP was isolated from a genomic library made from DNA of an A. fumigatus isolate. The nucleotide sequence of this gene was compared to that of a cDNA encoding A. oryzae ALP and to that of a cDNA from A. fumigatus encoding the mature ALP protein. Mature A. fumigatus ALP contains 282 amino acids and is encoded by three exons. The pre-proenzyme has a leader sequence of 121 amino acids.
PMID: 1601287 [PubMed - indexed for MEDLINE]
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Cited by 22 PubMed Central articles
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Sedolisins, a new class of secreted proteases from Aspergillus fumigatus with endoprotease or tripeptidyl-peptidase activity at acidic pHs.
Reichard U, Léchenne B, Asif AR, Streit F, Grouzmann E, Jousson O, Monod M.
Appl Environ Microbiol. 2006 Mar; 72(3):1739-48.
[Appl Environ Microbiol. 2006]
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Hoffman B, Breuil C.
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[Appl Environ Microbiol. 2004]
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[Antimicrob Agents Chemother. 2003]
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