Your browser version may not work well with NCBI's Web applications. More information here...
1: EMBO J. 2005 Jul 20;24(14):2688-99. Epub 2005 Jun 30.Click here to read Click here to read Links

Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin.

Edlich F, Weiwad M, Erdmann F, Fanghänel J, Jarczowski F, Rahfeld JU, Fischer G.

Max-Planck Research Unit for Enzymology of Protein Folding, Halle/Saale, Germany.

FKBP-type peptidyl prolyl cis/trans isomerases (PPIases) are folding helper enzymes involved in the control of functional regrowth of damaged sciatic, cortical cholinergic, dopaminergic and 5-HT neurones. Here, we show that the constitutively inactive human FK506-binding protein 38 (FKBP38) is capable of responding directly to intracellular Ca2+ rise through formation of a heterodimeric Ca2+/calmodulin/FKBP38 complex. Only complex formation creates an enzymatically active FKBP, displaying affinity for Bcl-2 mediated through the PPIase site. Association between Bcl-2 and the active site of Ca2+/calmodulin/FKBP38 regulates Bcl-2 function and thereby participates in the promotion of apoptosis in neuronal tissues. FKBP38 proapoptotic function mediated by this interaction is abolished by either potent inhibitors of the PPIase activity of the Ca2+/calmodulin/FKBP38 complex or RNA interference-mediated depletion of FKBP38, promoting neuronal cell survival.

PMID: 15990872 [PubMed - indexed for MEDLINE]

PMCID: PMC1176465

Patient Drug Information

  • Tacrolimus (Prograf® )

    Tacrolimus is used along with other medications to prevent rejection (attack of a transplanted organ by the immune system of a person receiving the organ) in people who have received kidney, liver, or heart transplants. ...

  • Source: AHFS Consumer Medication Information