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Quantification of cytochrome P450 reductase gene expression in human tissues.
Department of Biochemistry and Molecular Biology, University College London, United Kingdom.
We have isolated and sequenced cDNA clones that code for a variant of human cytochrome P450 reductase. An RNase protection assay was used to quantify the corresponding mRNA in adult and fetal tissues. The results demonstrate that, in the samples analyzed, the cytochrome P450 reductase gene displays very little inter-individual variation in its expression in adult liver and is subject to little developmental or tissue-specific regulation.
PMID: 1550342 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.
DeSilva U, Elnitski L, Idol JR, Doyle JL, Gan W, Thomas JW, Schwartz S, Dietrich NL, Beckstrom-Sternberg SM, McDowell JC, et al.
Genome Res. 2002 Jan; 12(1):3-15.
[Genome Res. 2002]
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Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains.
Smith GC, Tew DG, Wolf CR.
Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8710-4.
[Proc Natl Acad Sci U S A. 1994]