Cloning and domain structure of the mammalian spli...[Nature. 1992]

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1: Nature. 1992 Feb 13;355(6361):609-14. Links

Cloning and domain structure of the mammalian splicing factor U2AF.

Zamore PD, Patton JG, Green MR.

Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.

A complementary DNA clone encoding the large subunit of the essential mammalian pre-messenger RNA splicing component U2 snRNP auxiliary factor (U2AF65) has been isolated and expressed in vitro. It contains two functional domains: a sequence-specific RNA-binding region composed of three ribonucleoprotein-consensus sequence domains, and an arginine/serine-rich motif necessary for splicing but not for binding to pre-mRNA.

PMID: 1538748 [PubMed - indexed for MEDLINE]

Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon.
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[Mol Cell Biol. 1997]
The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability.
Science. 1993 Oct 22; 262(5133):569-73.

[Science. 1993]
Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae.
RNA. 1995 May; 1(3):260-72.

[RNA. 1995]
Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.
Mol Cell Biol. 1987 May; 7(5):1731-9.

[Mol Cell Biol. 1987]
Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects.
Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10333-7.

[Proc Natl Acad Sci U S A. 1996]
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Cited by over 100 PubMed Central articles

A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing.
Marengo MS, Wassarman DA. RNA. 2008 Aug; 14(8):1681-95. Epub 2008 Jul 2.

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Fas splicing regulation during early apoptosis is linked to caspase-mediated cleavage of U2AF65.
Izquierdo JM. Mol Biol Cell. 2008 Aug; 19(8):3299-307. Epub 2008 May 28.

[Mol Biol Cell. 2008]
Splicing factors SF1 and U2AF associate in extraspliceosomal complexes.
Rino J, Desterro JM, Pacheco TR, Gadella TW Jr, Carmo-Fonseca M. Mol Cell Biol. 2008 May; 28(9):3045-57. Epub 2008 Feb 19.

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