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Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors.
Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652.
A complementary DNA clone encoding a transporter for glycine has been isolated from rat brain, and its functional properties have been examined in mammalian cells. The transporter displays high affinity for glycine (KM approximately 100 microM) and is dependent on external Na+ and Cl-. Northern blot analysis indicates that the distribution of the mRNA encoding the glycine transporter is restricted to the nervous system. In situ hybridization data are consistent with roles for the transporter in both glycine neurotransmission and glycine modulation of N-methyl-D-aspartate (NMDA) receptors in the hippocampus. The identification of this transporter therefore opens the study of the molecular mechanisms underlying both inhibitory glycinergic transmission and NMDA-mediated excitatory transmission.
PMID: 1534013 [PubMed - indexed for MEDLINE]
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Cited by 24 PubMed Central articles
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Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice.
Martina M, B-Turcotte ME, Halman S, Tsai G, Tiberi M, Coyle JT, Bergeron R.
J Physiol. 2005 Mar 15; 563(Pt 3):777-93. Epub 2005 Jan 20.
[J Physiol. 2005]
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Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices.
Huang H, Barakat L, Wang D, Bordey A.
J Physiol. 2004 Nov 1; 560(Pt 3):721-36. Epub 2004 Aug 26.
[J Physiol. 2004]
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Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord.
Bradaïa A, Schlichter R, Trouslard J.
J Physiol. 2004 Aug 15; 559(Pt 1):169-86. Epub 2004 Jul 2.
[J Physiol. 2004]
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