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1: FEBS Lett. 2004 Jan 2;556(1-3):91-4.Click here to read Links

In vivo interaction between CDKA and eIF4A: a possible mechanism linking translation and cell proliferation.

Hutchins AP, Roberts GR, Lloyd CW, Doonan JH.

Department of Cell and Developmental Biology, John Innes Centre, NR4 7UH, Norwich, UK.

In a proteomics-based screen for proteins interacting with cyclin-dependent protein kinase (CDK), we have identified a novel CDK complex containing the eukaryotic translation initiation factor, eIF4A. Reciprocal immunoprecipitations using antibodies against eIF4A indicate that the interaction is specific. The CDKA-eIF4A complex is abundant in actively proliferating and growing cells but is absent from cells that have ceased dividing. The CDKA-eIF4A complex contains kinase activity that is sensitive to the CDK-specific inhibitor roscovitine. This interaction points to a possible molecular mechanism linking cell proliferation with translational control.

PMID: 14706832 [PubMed - indexed for MEDLINE]