Elongation factor-1 messenger-RNA levels in cultur...[Nucleic Acids Res. 1992]

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1: Nucleic Acids Res. 1992 Nov 25;20(22):5907-10. Links

Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation.

Sanders J, Maassen JA, Möller W.

Department of Medical Biochemistry, Sylvius Laboratory, State University of Leiden, The Netherlands.

Copy-DNA clones covering the complete coding sequence of human Elongation Factor-1 gamma mRNA have been isolated and characterized. The expression of Elongation Factor-1 in a variety of cell lines and a number of tissues shows a large increase in Elongation Factor-1 mRNA going from tissue to cultured cells (20-fold). Messenger-RNA levels for Elongation Factor-1 alpha, -1 beta and -1 gamma increase in parallel suggesting coordinate regulation of the expression of these genes. Oncogenic transformation in vitro does not strongly affect Elongation Factor-1 mRNA levels.

PMID: 1461723 [PubMed - indexed for MEDLINE]

PMCID: PMC334453

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