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1: Trends Mol Med. 2003 Oct;9(10):409-13.Click here to read Links

Death and the retrovirus.

Vartanian JP, Sommer P, Wain-Hobson S.

Unité de Rétrovirologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 cedex 15, Paris, France.

A flurry of new papers has shown that HIV reverse transcription is vulnerable to G-->A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.

PMID: 14557052 [PubMed - indexed for MEDLINE]

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