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- Erratum in:
- Nat Genet. 2005 May;37(5):555.
- Comment in:
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Nat Genet. 2003 Oct;35(2):116-7.
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Nat Genet. 2004 Jan;36(1):3; author reply 3-4.
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Nat Genet. 2006 Oct;38(10):1091-2; author reply 1092-3.
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.
Gretarsdottir S,
Thorleifsson G,
Reynisdottir ST,
Manolescu A,
Jonsdottir S,
Jonsdottir T,
Gudmundsdottir T,
Bjarnadottir SM,
Einarsson OB,
Gudjonsdottir HM,
Hawkins M,
Gudmundsson G,
Gudmundsdottir H,
Andrason H,
Gudmundsdottir AS,
Sigurdardottir M,
Chou TT,
Nahmias J,
Goss S,
Sveinbjörnsdottir S,
Valdimarsson EM,
Jakobsson F,
Agnarsson U,
Gudnason V,
Thorgeirsson G,
Fingerle J,
Gurney M,
Gudbjartsson D,
Frigge ML,
Kong A,
Stefansson K,
Gulcher JR.
deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland. solveig.gretarsdottir@decode.is
We previously mapped susceptibility to stroke to chromosome 5q12. Here we finely mapped this locus and tested it for association with stroke. We found the strongest association in the gene encoding phosphodiesterase 4D (PDE4D), especially for carotid and cardiogenic stroke, the forms of stroke related to atherosclerosis. Notably, we found that haplotypes can be classified into three distinct groups: wild-type, at-risk and protective. We also observed a substantial disregulation of multiple PDE4D isoforms in affected individuals. We propose that PDE4D is involved in the pathogenesis of stroke, possibly through atherosclerosis, which is the primary pathological process underlying ischemic stroke.
PMID: 14517540 [PubMed - indexed for MEDLINE]
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Cited by 27 PubMed Central articles
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Phosphodiesterase 4D gene and risk of noncardiogenic ischemic stroke in a Korean population.
Kim MK, Kim JT, Choi SM, Lee SH, Park MS, Cho KH.
J Korean Med Sci. 2009 Apr; 24(2):307-10. Epub 2009 Apr 20.
[J Korean Med Sci. 2009]
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Interobserver agreement in the trial of org 10172 in acute stroke treatment classification of stroke based on retrospective medical record review.
Meschia JF, Barrett KM, Chukwudelunzu F, Brown WM, Case LD, Kissela BM, Brown RD Jr, Brott TG, Olson TS, Rich SS, et al.
J Stroke Cerebrovasc Dis. 2006 Nov-Dec; 15(6):266-72.
[J Stroke Cerebrovasc Dis. 2006]
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Genome-wide association of sleep and circadian phenotypes.
Gottlieb DJ, O'Connor GT, Wilk JB.
BMC Med Genet. 2007 Sep 19; 8 Suppl 1:S9. Epub 2007 Sep 19.
[BMC Med Genet. 2007]
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