Your browser version may not work well with NCBI's Web applications. More information here...
1: FEBS Lett. 1992 Nov 2;312(1):53-6.Click here to read Links

Cloning and sequencing of a rat type II activin receptor.

Shinozaki H, Ito I, Hasegawa Y, Nakamura K, Igarashi S, Nakamura M, Miyamoto K, Eto Y, Ibuki Y, Minegishi T.

Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.

A full-length cDNA for a rat type II activin receptor was cloned by hybridization from a rat ovary cDNA library. The deduced amino acid sequence (513 residues) containing a single membrane-spanning domain and an intracellular kinase domain with predicted serine/threonine specificity. The amino acid sequence is 99.8% and 99.4% identical in the coding region with the previously cloned mouse and human type II activin receptor, and only 66.7% identical in the coding region with the previously cloned rat type IIB activin receptor. We examined the effect of PMSG-hCG on the mRNA level of type II activin receptor in immature rat ovaries. Northern blot analysis of ovarian RNA revealed two mRNAs (3.0 kb and 6.0 kb).

PMID: 1385212 [PubMed - indexed for MEDLINE]