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Molecular cloning of the interleukin-1 beta converting enzyme.
Cerretti DP,
Kozlosky CJ,
Mosley B,
Nelson N,
Van Ness K,
Greenstreet TA,
March CJ,
Kronheim SR,
Druck T,
Cannizzaro LA, et al.
Immunex Corporation, Seattle, WA 98101.
Interleukin-1 beta (IL-1 beta) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor. A complementary DNA encoding a protease that carries out this cleavage has been cloned. Recombinant expression in COS-7 cells enabled the cells to process precursor IL-1 beta to the mature form. Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.
PMID: 1373520 [PubMed - indexed for MEDLINE]
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Cited by 64 PubMed Central articles
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Large-scale preparation of active caspase-3 in E. coli by designing its thrombin-activatable precursors.
Kang HJ, Lee YM, Jeong YJ, Park K, Jang M, Park SG, Bae KH, Kim M, Chung SJ.
BMC Biotechnol. 2008 Dec 11; 8:92. Epub 2008 Dec 11.
[BMC Biotechnol. 2008]
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P2 purinergic receptor modulation of cytokine production.
Gabel CA.
Purinergic Signal. 2007 Mar; 3(1-2):27-38. Epub 2007 Jan 3.
[Purinergic Signal. 2007]
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ReviewMolecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.
Schroeder GN, Hilbi H.
Clin Microbiol Rev. 2008 Jan; 21(1):134-56.
[Clin Microbiol Rev. 2008]
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