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1: Biochem Biophys Res Commun. 1992 Mar 16;183(2):672-9.Click here to read Links

Molecular cloning and characterization of a novel rat activin receptor.

Legerski R, Zhou X, Dresback J, Eberspaecher H, McKinney S, Segarini P, de Crombrugghe B.

Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston 77030.

We report the isolation of a full-length rat cDNA for a new activin receptor. The deduced amino acid sequence of this receptor shows 67 percent overall identity with that of a previously identified mouse activin receptor. As predicted for the mouse activin receptor, the amino acid sequence of the rat receptor is consistent with a polypeptide containing an extracellular ligand binding domain, a hydrophobic transmembrane domain, and a serine/threonine kinase intracellular domain. In an expression assay, this new receptor was found to bind I125 radiolabeled activin.

PMID: 1312838 [PubMed - indexed for MEDLINE]