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1: Neuron. 1992 Jan;8(1):169-79.Click here to read Links

A family of metabotropic glutamate receptors.

Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S.

Institute for Immunology, Kyoto University Faculty of Medicine, Japan.

Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.

PMID: 1309649 [PubMed - indexed for MEDLINE]