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High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Morphochem AG, Basel, Switzerland. christian.oefner@morphochem.ch
Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine has been solved, revealing the nature of the covalent interaction with the active-site serine.
PMID: 12832764 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase.
Wright H, Kiss AL, Szeltner Z, Polgár L, Fülöp V.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1; 61(Pt 10):942-4. Epub 2005 Sep 30.
[Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005]
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Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation.
Aertgeerts K, Ye S, Tennant MG, Kraus ML, Rogers J, Sang BC, Skene RJ, Webb DR, Prasad GS.
Protein Sci. 2004 Feb; 13(2):412-21. Epub 2004 Jan 10.
[Protein Sci. 2004]
Structures reported by this article