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1: J Invest Dermatol. 1992 Dec;99(6):886-91.Links
Corrected and republished from:
J Invest Dermatol 1992 Oct;99(4):381-5.

The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44.

Kugelman LC, Ganguly S, Haggerty JG, Weissman SM, Milstone LM.

Dermatology Service 185, VA Medical Center, West Haven, CT 06516.

Epican, a heparan sulfate proteoglycan, was recently identified on the surface of keratinocytes with the aid of a monoclonal antibody to its core protein. Using that antibody to screen a human keratinocyte cDNA library, a clone encoding the entire epican core protein was selected and sequenced. The core protein of epican is a form of CD44. The deduced protein sequence of 699 amino acids has a novel 339 amino acid domain inserted into the proximal extracellular domain of the standard, leukocyte form of CD44. The additional domain adds a number of potential N- and O-linked glycosylation sites and two proteolysis sites to this form of CD44.

PMID: 1281868 [PubMed - indexed for MEDLINE]