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The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.
Department of Biochemistry, University of Oxford, United Kingdom.
We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.
PMID: 12719519 [PubMed - indexed for MEDLINE]
PMCID: PMC156333
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Cited by 20 PubMed Central articles
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Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles.
Steinmann E, Brohm C, Kallis S, Bartenschlager R, Pietschmann T.
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[J Virol. 2008]
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Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus.
Russell RS, Meunier JC, Takikawa S, Faulk K, Engle RE, Bukh J, Purcell RH, Emerson SU.
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[Proc Natl Acad Sci U S A. 2008]
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Iminosugars in combination with interferon and ribavirin permanently eradicate noncytopathic bovine viral diarrhea virus from persistently infected cells.
Woodhouse SD, Smith C, Michelet M, Branza-Nichita N, Hussey M, Dwek RA, Zitzmann N.
Antimicrob Agents Chemother. 2008 May; 52(5):1820-8. Epub 2008 Mar 3.
[Antimicrob Agents Chemother. 2008]
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