Biosynthesis and processing of pro CCK: recent pro...[Life Sci. 2003]

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1: Life Sci. 2003 Jan 3;72(7):747-57. Links

Biosynthesis and processing of pro CCK: recent progress and future challenges.

Beinfeld MC.

Department of Pharmacology and Experimental Therapeutics, School of Medicine, Tufts University, 136 Harrison Ave., Boston, MA 02111, USA. Margery.Beinfeld@tufts.edu

Pro Cholecystokinin (CCK) like other prohormones that pass through the regulated secretory pathway, undergoes a number of post-translational modifications during its biosynthesis including tyrosine sulfation, endoproteolytic cleavages, trimming by carboxypeptidase and c-terminal amidation. This minireview summarizes what is known about this process, what specific enzymes are involved in endocrine and neuronal tumor cells and in mutant and knockout mouse strains. It also points out the major challenges that remain for future research.

PMID: 12479974 [PubMed - indexed for MEDLINE]

ReviewCCK biosynthesis and processing: recent progress and future challenges.
Life Sci. 1997; 61(24):2359-66.

[Life Sci. 1997]
Prohormone convertase 1 (PC1) when expressed with pro cholecystokinin (pro CCK) in L cells performs three endoproteolytic cleavages which are observed in rat brain and in CCK-expressing endocrine cells in culture, including the production of glycine and arginine extended CCK8.
Biochem Biophys Res Commun. 1998 Jul 30; 248(3):538-41.

[Biochem Biophys Res Commun. 1998]
Biosynthesis and post-translational processing of site-directed endoproteolytic cleavage mutants of Pro-CCK in AtT-20 cells.
Biochemistry. 2002 Jan 15; 41(2):570-8.

[Biochemistry. 2002]
Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells.
Biochemistry. 2000 Nov 14; 39(45):13825-30.

[Biochemistry. 2000]
ReviewPeptide hormone precursor processing: getting sorted?
Mol Cell Endocrinol. 1999 Oct 25; 156(1-2):1-6.

[Mol Cell Endocrinol. 1999]
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