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1: Science. 2002 Oct 18;298(5593):584-6.Click here to read Links
Comment in:
Science. 2002 Oct 18;298(5593):547.

Self-assembly of highly phosphorylated silaffins and their function in biosilica morphogenesis.

Kröger N, Lorenz S, Brunner E, Sumper M.

Lehrstuhl Biochemie I, Institut für Biophysik und Physikalische Biochemie, Universität Regensburg, 93053 Regensburg, Germany.

Silaffins are uniquely modified peptides that have been implicated in the biogenesis of diatom biosilica. A method that avoids the harsh anhydrous hydrogen fluoride treatment commonly used to dissolve biosilica allows the extraction of silaffins in their native state. The native silaffins carry further posttranslational modifications in addition to their polyamine moieties. Each serine residue was phosphorylated, and this high level of phosphorylation is essential for biological activity. The zwitterionic structure of native silaffins enables the formation of supramolecular assemblies. Time-resolved analysis of silica morphogenesis in vitro detected a plastic silaffin-silica phase, which may represent a building material for diatom biosilica.

PMID: 12386330 [PubMed - indexed for MEDLINE]

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