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1: Science. 2002 Oct 4;298(5591):176-8.Click here to read Links

G protein-coupled receptors in Anopheles gambiae.

Hill CA, Fox AN, Pitts RJ, Kent LB, Tan PL, Chrystal MA, Cravchik A, Collins FH, Robertson HM, Zwiebel LJ.

Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.

We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.

PMID: 12364795 [PubMed - indexed for MEDLINE]