MAP kinase module: the Ksr connection.

Laboratory of Intracellular Signaling, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, PQ Canada, H2W 1R7.

Ksr has been genetically defined as a component of the Ras/MAP kinase pathway, but its role has been unclear. New studies now provide evidence that Ksr is important for signal transmission within the MAP kinase module, where it apparently acts as a location-regulated scaffold connecting MEK to Raf.

PMID: 12007434 [PubMed - indexed for MEDLINE]