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1: Biosci Biotechnol Biochem. 2001 Oct;65(10):2353-7. Links

Purification and some properties of an inhibitor for a yeast pleiotropic drug resistant pump from Kitasatospora sp. E-420.

Wanigasekera A, Hiraga K, Hamanaka N, Oda K.

Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology, Matsugasaki, Japan.

A strain producing an inhibitor for pleiotropic drug resistant 5 (Pdr5) was isolated using our original screening system in yeast. The strain was classified and named as Kitasatospora sp. E-420. The purified inhibitor (molecular weight = 1,193 by FAB-MS) inhibited a Pdr5-mediated efflux of cycloheximide and cerulenin. The intracellular accumulation of a fluorescent dye, rhodamine 123, by the inhibitor was also confirmed. Some physicochemical data suggested that the Pdr5-specific inhibitor was different from an immunosuppressant, FK506, reported as the only inhibitor of Pdr5 in vivo.

PMID: 11758940 [PubMed - indexed for MEDLINE]