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1: Arch Immunol Ther Exp (Warsz). 2001;49(4):279-83.Links

Multi-functional roles of Stat3 revealed by conditional gene targeting.

Takeda K, Akira S.

Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. ktakeda@biken.osaka-u.ac.jp

Signal transducer and activator of transcription (STAT) is a family of transcription factors composed of seven members. Gene-targeted mice of each STAT family protein displayed defective responses to cytokines, demonstrating an important role in cytokine-mediated biological responses. However, unlike the mice lacking other STAT proteins, Stat3-deficient mice died during their early embryogenesis. Therefore, in an attempt to avoid the lethality and assess the role of Stat3 in cytokine-mediated functions in mouse adult tissues, conditional gene targeting utilizing a Cre-loxP system was achieved. By this method, Stat3 was disrupted in several types of tissue, including T cells, macrophages, skin, and mammary gland. Analyses of these Stat3-mutant mice revealed important roles of Stat3 in biological functions in each tissue.

PMID: 11726030 [PubMed - indexed for MEDLINE]