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Amino acid sequence of a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian tiger snake).
The complete amino acid sequence of notexin, a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian tiger snake), has been elucidated. The protein consists of a single chain of 119 amino acids cross-linked by seven disulfide bridges and has a formula weight of 13,578. The main fragmentation of the peptide chain was accomplished with a staphylococcal protease specific for glutamoyl bonds. A cyanogen bromide fragment and tryptic peptides were used to align the five major staphylococcal protease peptides. The sequence was determined by Edman degradation using the direct phenylthiohydantoin method and with carboxypeptidase A. Notexin is shown to be homologous to both porcine pancreatic phospholipase A and a phospholipase A from the venom of Naja melanoleuca.
PMID: 1158892 [PubMed - indexed for MEDLINE]
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Cited by 12 PubMed Central articles
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Sites of action of Mojave toxin isolated from the venom of the Mojave rattlesnake.
Gopalakrishnakone P, Hawgood BJ, Holbrooke SE, Marsh NA, Santana De Sa S, Tu AT.
Br J Pharmacol. 1980 Jul; 69(3):421-31.
[Br J Pharmacol. 1980]
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Venom from the snake Bothrops asper Garman. Purification and characterization of three phospholipases A2.
Alagón AC, Molinar RR, Possani LD, Fletcher PL Jr, Cronan JE Jr, Julia JZ.
Biochem J. 1980 Mar 1; 185(3):695-704.
[Biochem J. 1980]
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A study on the interaction of crotapotin with crotoxin phospholipase A2, notexin and other presynaptic neurotoxins.
Chang CC, Su MJ.
Br J Pharmacol. 1981 Jun; 73(2):495-503.
[Br J Pharmacol. 1981]
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