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1: Biochem Biophys Res Commun. 2001 Sep 14;287(1):83-91.Click here to read Links

Identification and expression of a new sulfhydryl oxidase SOx-3 during the cell cycle and the estrus cycle in uterine cells.

Musard JF, Sallot M, Dulieu P, Fraîchard A, Ordener C, Remy-Martin JP, Jouvenot M, Adami P.

Institut d'Etude et de Transfert de Gènes, Bâtiment INSERM, 25030 Besançon cedex, France.

Using differential hybridization of a guinea pig endometrial cell cDNA library, a potentially negatively estrogen-regulated gene, SOX-3, was isolated. According to the nucleotide and protein sequence similarities, SOx-3 belonged to the FAD-linked sulfhydryl oxidase family containing the egg white sulfhydryl oxidase, the rat seminal vesicle sulfhydryl oxidase-2 SOx-2, the quiescence-inducible protein hQ6. The SOX-3 transcript in the guinea pig as well as 5 different mRNAs in human tissues appeared differentially expressed in the tissues studied. In secondary endometrial cell culture, the SOX-3 mRNA level increased during a serum depletion-induced quiescence, decreased when cells enter the G1 phase after serum stimulation, and was restored during the S and G2/M phases. Thus, SOX-3 could be implicated in the negative cell cycle control. The SOx-3 protein appeared to be specific of epithelial cells in the uterus. Its expression level varied during the estrus cycle in the guinea pig, suggesting a regulation by steroid hormones. Copyright 2001 Academic Press.

PMID: 11549257 [PubMed - indexed for MEDLINE]

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