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1: Protein Sci. 2001 Jun;10(6):1264-7.Click here to read Click here to read Links

Disulfide structure of alfimeprase: a recombinant analog of fibrolase.

Jones G, Ronk M, Mori F, Zhang Z.

Analytical Research & Development Department, Amgen Inc., Thousand Oaks, California 91320, USA.

The disulfide structure of alfimeprase, a recombinant analog of fibrolase, was experimentally determined by a combination of peptide mapping, Edman degradation, and mass spectrometry. The three disulfide bonds were determined to be Cys-116/196, Cys-156 /180, and Cys-158/163 with the residue number system of alfimeprase.

PMID: 11369866 [PubMed - indexed for MEDLINE]

PMCID: PMC2374009