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Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response.
The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis. Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCFTIR1. Furthermore, we found that the COP9 signalosome and SCFTIR1 interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCFTIR1. Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase-mediated responses.
PMID: 11337587 [PubMed - indexed for MEDLINE]
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Cited by 76 PubMed Central articles
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Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana.
Gilkerson J, Hu J, Brown J, Jones A, Sun TP, Callis J.
Genetics. 2009 Mar; 181(3):945-63. Epub 2008 Dec 29.
[Genetics. 2009]
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The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.
Rencus-Lazar S, Amir Y, Wu J, Chien CT, Chamovitz DA, Segal D.
PLoS One. 2008 May 21; 3(5):e2239. Epub 2008 May 21.
[PLoS One. 2008]
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Auxin responses in mutants of the Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome.
Dohmann EM, Levesque MP, Isono E, Schmid M, Schwechheimer C.
Plant Physiol. 2008 Jul; 147(3):1369-79. Epub 2008 May 8.
[Plant Physiol. 2008]
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