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1: Tissue Antigens. 2000 Aug;56(2):159-61.Click here to read Links

Identification of two novel human CD1E alleles.

Mirones I, Oteo M, Parra-Cuadrado JF, Martínez-Naves E.

Unidad de Inmunología, Facultad de Medicina, Universidad Complutense, Madrid, Spain.

CD1 is a family of proteins structurally related to major histocompatibility complex (MHC) molecules and specialized in presenting lipids or glycolipids to T cells. In humans, there are five CD1 genes (CD1A to CD1E). It has been shown that, in contrast with classical MHC genes, CD1 loci display a very limited polymorphism. In the present work we describe two novel CD1E alleles found in two healthy Caucasian individuals. One allele differs from the wild-type by a point mutation resulting in a replacement of arginine at position 154 by a tryptophan. In the second allele we found a substitution of the leucine 184 by a proline.

PMID: 11019917 [PubMed - indexed for MEDLINE]