GATE-16, a membrane transport modulator, interacts...[EMBO J. 2000]

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1: EMBO J. 2000 Apr 3;19(7):1494-504. Links

GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28.

Sagiv Y, Legesse-Miller A, Porat A, Elazar Z.

Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100 Israel.

Membrane proteins located on vesicles (v-SNAREs) and on the target membrane (t-SNAREs) mediate specific recognition and, possibly, fusion between a transport vesicle and its target membrane. The activity of SNARE molecules is regulated by several soluble cytosolic proteins. We have cloned a bovine brain cDNA encoding a conserved 117 amino acid polypeptide, denoted Golgi-associated ATPase Enhancer of 16 kDa (GATE-16), that functions as a soluble transport factor. GATE-16 interacts with N-ethylmaleimidesensitive factor (NSF) and significantly stimulates its ATPase activity. It also interacts with the Golgi v-SNARE GOS-28 in an NSF-dependent manner. We propose that GATE-16 modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation.

PMID: 10747018 [PubMed - indexed for MEDLINE]

PMCID: PMC310219

Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion.
J Cell Biol. 2002 Jun 24; 157(7):1161-73. Epub 2002 Jun 17.

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Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.
J Biol Chem. 2001 Aug 3; 276(31):29456-65. Epub 2001 May 30.

[J Biol Chem. 2001]
ReviewSNAREs and membrane fusion in the Golgi apparatus.
Biochim Biophys Acta. 1998 Aug 14; 1404(1-2):9-31.

[Biochim Biophys Acta. 1998]
ReviewN-ethylmaleimide sensitive factor (NSF) structure and function.
Int Rev Cytol. 2001; 207:71-112.

[Int Rev Cytol. 2001]
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Structures reported by this article

Crystal Structure Of Gate-16

PDB: 1EO6

Source: Bos taurus

Method: X-Ray Diffraction | Resolution: 1.8 Å

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