Cell-substrate interactions and signaling through ...[Curr Opin Cell Biol. 2000]

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1: Curr Opin Cell Biol. 2000 Apr;12(2):250-6. Links

Cell-substrate interactions and signaling through ILK.

Dedhar S.

Department of Biochemistry, University of British Columbia, BC Cancer Agency and Vancouver Hospital, Jack Bell Research Center, Vancouver, BC, V6H 3Z6, Canada. sdedhar@interchange.ubc.ca

Interactions between cells and the extracellular matrix (ECM) result in the regulation of cell growth, cell differentiation and cell migration. These interactions are mediated by integrins and growth factor receptors and intracellular effectors that couple these receptors to downstream components are key to the transduction of ECM signals. This review summarizes recent advances in our understanding of signal transduction via integrins, focusing on the role of integrin-linked kinase in some of these pathways. Research into this interesting protein is uncovering novel aspects of coordinated signaling by the ECM and growth factors.

PMID: 10712922 [PubMed - indexed for MEDLINE]

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Trends Cell Biol. 1999 Aug; 9(8):319-23.

[Trends Cell Biol. 1999]
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[Int J Mol Med. 1999]
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[Curr Opin Hematol. 1999]
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J Cell Biol. 2001 Nov 12; 155(4):505-10. Epub 2001 Nov 5.

[J Cell Biol. 2001]
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[J Mammary Gland Biol Neoplasia. 2003]
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