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1: J Mol Biol. 2000 Feb 4;295(5):1185-200.Click here to read Links

Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing.

Soloviev MM, Ciruela F, Chan WY, McIlhinney RA.

Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford, OX1 3TH, UK. mikhail.soloviev@pharm.ox.ac.uk

Homer proteins bind specifically to the C termini of the metabotropic glutamate receptor mGluR1alpha/a and mGluR5, play a role in their targeting and modulate their synaptic properties. We have discovered that extensive alternative splicing generates a family of 17 Homer proteins. These fall into two distinct groups of 12 "long" Homers, which all have a coiled-coil domain at their C termini, and five "short" Homers, which lack such a domain. All Homers contain the N-terminal sequence responsible for their binding to mGluR1alpha/a receptors and can be co-localised with the recombinantly expressed mGluR1alpha/a protein in HEK-293 cells. The existence of the long and the short variants of each of the Homer-1, Homer-2 and Homer-3 proteins reflects the fundamental principles of Homer functions. Copyright 2000 Academic Press.

PMID: 10653696 [PubMed - indexed for MEDLINE]