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1: Cancer Res. 1999 Aug 1;59(15):3741-7.Click here to read Links

Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.

Numata S, Claudio PP, Dean C, Giordano A, Croce CM.

Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.

PMID: 10446990 [PubMed - indexed for MEDLINE]