Your browser version may not work well with NCBI's Web applications. More information here...
1: Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7415-20.Click here to read Click here to read Links

Efficient export of the glucose transporter Hxt1p from the endoplasmic reticulum requires Gsf2p.

Sherwood PW, Carlson M.

Department of Genetics and Development, Columbia University, New York, NY 10032, USA.

Mutations in the GSF2 gene cause glucose starvation phenotypes in Saccharomyces cerevisiae. We have isolated the HXT1 gene, which encodes a low-affinity, high-capacity glucose transporter, as a multicopy suppressor of a gsf2 mutation. We show that gsf2 mutants accumulate Hxt1p in the endoplasmic reticulum (ER) and that Gsf2p is a 46-kDa integral membrane protein localized to the ER. gsf2 mutants also display a galactose growth defect and abnormal localization of the galactose transporter Gal2p but are not defective in function or localization of the high-affinity glucose transporter Hxt2p. These findings suggest that Gsf2p functions in the ER to promote the secretion of certain hexose transporters.

PMID: 10377429 [PubMed - indexed for MEDLINE]

PMCID: PMC22100