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Science. 1999 Jun 4;284(5420):1600.
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Science. 1999 Jun 4;284(5420):1600-1.
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Tortorella MD,
Burn TC,
Pratta MA,
Abbaszade I,
Hollis JM,
Liu R,
Rosenfeld SA,
Copeland RA,
Decicco CP,
Wynn R,
Rockwell A,
Yang F,
Duke JL,
Solomon K,
George H,
Bruckner R,
Nagase H,
Itoh Y,
Ellis DM,
Ross H,
Wiswall BH,
Murphy K,
Hillman MC Jr,
Hollis GF,
Newton RC,
Magolda RL,
Trzaskos JM,
Arner EC.
Department of Inflammatory Diseases Research, DuPont Pharmaceuticals Company, Wilmington, DE 19880-0400, USA.
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373-alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.
PMID: 10356395 [PubMed - indexed for MEDLINE]
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Cited by 38 PubMed Central articles
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Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.
Luan Y, Kong L, Howell DR, Ilalov K, Fajardo M, Bai XH, Di Cesare PE, Goldring MB, Abramson SB, Liu CJ.
Osteoarthritis Cartilage. 2008 Nov; 16(11):1413-20. Epub 2008 May 15.
[Osteoarthritis Cartilage. 2008]
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The secreted metalloprotease ADAMTS20 is required for melanoblast survival.
Silver DL, Hou L, Somerville R, Young ME, Apte SS, Pavan WJ.
PLoS Genet. 2008 Feb 29; 4(2):e1000003. Epub 2008 Feb 29.
[PLoS Genet. 2008]
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Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain.
Ajmo JM, Eakin AK, Hamel MG, Gottschall PE.
BMC Neurosci. 2008 Jan 25; 9:14. Epub 2008 Jan 25.
[BMC Neurosci. 2008]
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