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Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients.
Shimura H,
Hattori N,
Kubo S,
Yoshikawa M,
Kitada T,
Matsumine H,
Asakawa S,
Minoshima S,
Yamamura Y,
Shimizu N,
Mizuno Y.
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Autosomal recessive juvenile parkinsonism (AR-JP) is a distinct clinical entity characterized by a selective degeneration of nigral neurons. Recently, the parkin gene responsible for AR-JP has been identified. Now, we report the subcellular localization of Parkin protein in patients with AR-JP or Parkinson's disease (PD) and in controls by immunoblotting and immunohistochemistry using antibodies raised against the Parkin molecule. Parkin protein was absent in all regions of the brains of patients with AR-JP. Parkin protein was not decreased in the brains of sporadic PD patients. Immunoreactivity was detected in a few Lewy bodies. Parkin protein was located in both the Golgi complex and cytosol.
PMID: 10319893 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Combined kinase inhibition modulates parkin inactivation.
Rubio de la Torre E, Luzón-Toro B, Forte-Lago I, Minguez-Castellanos A, Ferrer I, Hilfiker S.
Hum Mol Genet. 2009 Mar 1; 18(5):809-23. Epub 2008 Dec 2.
[Hum Mol Genet. 2009]
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
Narendra D, Tanaka A, Suen DF, Youle RJ.
J Cell Biol. 2008 Dec 1; 183(5):795-803. Epub 2008 Nov 24.
[J Cell Biol. 2008]
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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.
Deng H, Dodson MW, Huang H, Guo M.
Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14503-8. Epub 2008 Sep 17.
[Proc Natl Acad Sci U S A. 2008]
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