Your browser version may not work well with NCBI's Web applications. More information here...

1: UBA5 ubiquitin-like modifier activating enzyme 5 [ Homo sapiens ]

GeneID: 79876 updated 05-Jul-2009

[Top][Help]Summary

Official Symbol
UBA5provided by HGNC
Official Full Name
ubiquitin-like modifier activating enzyme 5provided by HGNC
Primary source
HGNC:23230
See related
Ensembl:ENSG00000081307; HPRD:15598; MIM:610552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THIFP1; UBE1DC1; FLJ17281; FLJ23251; FLJ23251UBA5; UBA5
Summary
This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

Go to reference sequence detailsTry our new Sequence Viewer




Genomic context[Top][Help]

chromosome: 3; Location: 3q22.1See UBA5 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

PubMed 1. UBE1DC1 greatly activated SUMO2 in the nucleus or transferred activated-SUMO2 to nucleus after it conjugated SUMO2 in the cytoplasm.
Submit: New GeneRIFCorrection

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
Two-hybrid
  BioGRID:122964   BioGRID:106824   APEH     BioGRID   PubMed
Two-hybrid
  BioGRID:122964   BioGRID:116473   GABARAPL2     BioGRID   PubMed
Affinity Capture-Western
  BioGRID:122964   BioGRID:112497   SUMO2     BioGRID   PubMed

[Top][Help]General gene information

Markers

SHGC-35962(e-PCR)
Links: UniSTS:80904
Alternate name: RH37826
STS-H07121(e-PCR)
Links: UniSTS:72122
Alternate names: RH41487; sts-H07121
STS-Z40704(e-PCR)
Links: UniSTS:78042
Alternate names: RH36756; sts-Z40704

Homology

Mouse, Rat
Map Viewer

GeneOntology Provided by GOA

Function Evidence
binding IEA
catalytic activity IEA
Process Evidence
metabolic process IEA
modification-dependent protein catabolic process IEA
Component Evidence
cytoplasm
PubMed 11256614		 IDA PubMed

Related pseudogene(s)

1 found Review record(s) in Gene

[Top][Help]General protein information

Preferred Names
ubiquitin-activating enzyme 5
Names
ubiquitin-activating enzyme 5
UFM1-activating enzyme
UBA5, ubiquitin-activating enzyme E1 homolog
ubiquitin-activating enzyme E1-domain containing 1

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_024818.3→NP_079094.1 ubiquitin-activating enzyme 5 isoform 1

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY253672,BQ581736,DB082596
    Consensus CDS
    CCDS3076.1
    UniProtKB/Swiss-Prot
    Q9GZZ9
    Conserved Domains (2) summary
    cd00757
    Location:52–297
    Blast Score:524
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...
    TIGR02356
    Location:53–273
    Blast Score:240
    adenyl_thiF; thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily

  2. NM_198329.2→NP_938143.1 ubiquitin-activating enzyme 5 isoform 2

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon, as compared to variant 1. The encoded isoform (2) is thus shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AY253672,BQ581736,DB457433
    Consensus CDS
    CCDS3077.1
    UniProtKB/TrEMBL
    A6NJL3
    UniProtKB/Swiss-Prot
    Q9GZZ9
    Conserved Domains (2) summary
    cd00757
    Location:1–241
    Blast Score:505
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...
    TIGR02356
    Location:1–217
    Blast Score:228
    adenyl_thiF; thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000003.11 Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

    Range
    132373290..132396944
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

  2. NT_005612.16

    Range
    38868436..38892090
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000046.1 Alternate assembly (Celera)

    Range
    130798783..130822433
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

  2. NW_921807.1

    Range
    38984453..39008103
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000135.1 Alternate assembly (HuRef)

    Range
    129776587..129753023, complement
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

  2. NW_001838884.2

    Range
    61676009..61652445, complement
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

Nucleotide   Protein
Genomic   AC020632.16 (1482..18958, complement)    None
Genomic   CH471052.2   EAW79189.1
    EAW79190.1
    EAW79191.1
    EAW79192.1
mRNA   AB154406.1   BAD15375.1
mRNA   AK026904.1   BAB15587.1
mRNA   AK027563.1   BAB55199.1
mRNA   AK056238.1    None
mRNA   AK129616.1    None
mRNA   AK310239.1    None
mRNA   AL136757.1   CAB66691.1
mRNA   AL832669.1    None
mRNA   AY253672.1   AAP79600.1
mRNA   BC009737.1   AAH09737.1
mRNA   BC048015.1    None
mRNA   BM541647.1    None
mRNA   BQ581736.1    None
mRNA   BU739244.1    None
mRNA   CR615958.1    None
mRNA   DB082596.1    None
mRNA   DB457433.1    None
Synthetic   AM392525.1   CAL37403.1
Synthetic   AM393124.1   CAL38002.1
Protein Accession   Links
Q9GZZ9.1   GenPept   UniProtKB/Swiss-Prot