Official Symbol

UBA7provided by HGNC

Official Full Name

ubiquitin-like modifier activating enzyme 7provided by HGNC

Primary source

HGNC:12471

See related

Ensembl:ENSG00000182179; HPRD:01873; MIM:191325

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

D8; UBE2; UBA1B; UBE1L; MGC12713; UBA7

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 3; Location: 3p21See UBA7 in MapViewer

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

	1.	UBE1L-ISG15 preferentially inhibits cyclin D1 in lung cancer
	2.	Ube1L was required for transfer of ISG15 to UbcH8 and for binding of Ube1L to UbcH8
	3.	RA treatment of APL and other RA-responsive leukemic cells induced expression of UBE1L and ISG15 as well as intracellular ISG15 conjugates. A physical association was found between UBE1L and ISG15 in vivo.
	4.	UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia

Markers

Homology

GeneOntology Provided by GOA

Preferred Names

ubiquitin-like modifier activating enzyme 7

Names

ubiquitin-like modifier activating enzyme 7

ubiquitin-activating enzyme-2

ubiquitin-activating enzyme E1-like

UBA7, ubiquitin-activating enzyme E1

UBA1, ubiquitin-activating enzyme E1 homolog B

ubiquitin-activating enzyme E1-related protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_003335.2→NP_003326.2 ubiquitin-like modifier activating enzyme 7

   Source sequence(s)

   BC006378,BM152341,CA425139

   Consensus CDS

   CCDS2805.1

   UniProtKB/Swiss-Prot

   P41226

   Conserved Domains (5) summary

   cd01490
   Location:434–743
   Blast Score:1004

   Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1)...

   cd01491
   Location:14–257
   Blast Score:948

   Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1)...

   cl00287
   Location:808–967
   Blast Score:455
   Location:357–399
   Blast Score:205

   E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...

   TIGR01408
   Location:10–1010
   Blast Score:1936

   Ube1; ubiquitin-activating enzyme E1

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000003.11 Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

   Range

   49851391..49842638, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

2. NT_022517.18

   Range

   49791391..49782638, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000046.1 Alternate assembly (Celera)

   Range

   49816714..49808165, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

2. NW_921651.1

   Range

   49816714..49808165, complement

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000135.1 Alternate assembly (HuRef)

   Range

   49901688..49910451

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

2. NW_001838877.2

   Range

   16357212..16365975

   Download

   GenBank  FASTA Sequence Viewer (Graphics)

• MIM 191325
• PharmGKB PA37121
• HPRD 01873
• UCSC UCSC
• UniGene Hs.16695