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1: STX1A syntaxin 1A (brain) [ Homo sapiens ]

GeneID: 6804 updated 05-Jul-2009

[Top][Help]Summary

Official Symbol
STX1Aprovided by HGNC
Official Full Name
syntaxin 1A (brain)provided by HGNC
Primary source
HGNC:11433
See related
Ensembl:ENSG00000106089; HPRD:01721; MIM:186590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STX1; HPC-1; p35-1; STX1A
Summary
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer




Genomic context[Top][Help]

chromosome: 7; Location: 7q11.23See STX1A in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

PubMed 1. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.(
PubMed 2. Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3.
PubMed 3. STX1A might influence the serotonergic system during neurodevelopment
PubMed 4. SNARE complex-related genes STX1A, VAMP2 and SNAP25 do not play a major role in susceptibility to schizophrenia in the Japanese population
PubMed 5. The expression of the SNARE protein SNAP-25 and its cellular homologue SNAP-23, as well as syntaxin1 and VAMP (vesicle-associated membrane protein) in samples of normal parathyroid tissue, chief cell adenoma, and parathyroid carcinoma, was examined.
PubMed 6. A lower frequency of the PRM -352T allele of the STX1A gene in overweight/obese subjects impaires glucose regulation, particularly among individuals with combined glucose intolerance and overt diabetes.
PubMed 7. Observational study of gene-disease association. (HuGE Navigator)
PubMed 8. We have identified a new three-gene classifier that is independent of and improves on stage to stratify early-stage NSCLC patients with significantly different prognoses.
PubMed 9. Norepinephrine transpossrter/syntaxin 1A complex rapidly redistributes, upon amphetamine treatment, when mechanisms supported by the transporter's NH2 terminus are eliminated.
PubMed 10. Syntaxin-1A actions on sulfonylurea receptor 2A blocks acidic pH-induced cardiac K(ATP) channel activation
PubMed 11. SNAP-25 traffics to the plasma membrane by a syntaxin-independent mechanism.
PubMed 12. cleavage of APP but not syntaxin 1 is independent of cell surface regulation by extracellular ligands
PubMed 13. A significant genetic association was found between schizophrenia and an intron 7 single nucleotide polymorphism (SNP) tested. Haplotype analysis supported the association with several significant values that appear to be driven by the intron 7 SNP.
PubMed 14. interacts with CFTR protein differently from interactions with SNARE.
PubMed 15. Syn-1A binds both NBFs of SUR1 and SUR2A but appears to exhibit distinct interactions with NBF2 of these SUR proteins in modulating the KATP channels in islet beta cells and cardiac myocytes
PubMed 16. Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis
PubMed 17. Munc18b binds to syntaxins 1A, 2, and 3 and regulates vesicle transport to the apical plasma membrane
PubMed 18. the mechanisms involved in Syn1A-K(v) interactions vary significantly between K(v) channels, thus providing a wide scope for Syn1A modulation of exocytosis and membrane excitability
PubMed 19. interacts with dopamine transporter
PubMed 20. CFTR channels are coordinately regulated by two cognate t-SNAREs, SNAP-23 (synaptosome-associated protein of 23 kDa) and syntaxin 1A.
PubMed 21. analysis of the spatially distinct modes of munc18-syntaxin 1 interaction
PubMed 22. the H(abc) domain has a role in membrane trafficking and targeting of syntaxin 1A

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_004594.1   MINT1   APBA1     HPRD   PubMed
 
  NP_004594.1   Calcium channel voltage dependent, L type alpha 1D subunit   CACNA1D     HPRD   PubMed
 
  NP_004594.1   Cyclin dependent kinase 5   CDK5     HPRD   PubMed
 
  NP_004594.1   NP_000483.2   CFTR     HPRD   PubMed
Syntaxin 1A interacts with CFTR.
  NP_004594.1   NP_000483.2   CFTR     BIND   PubMed
 
  NP_004594.1   Complexin 1   CPLX1     HPRD   PubMed
 
  NP_004594.1   KCNB1   KCNB1     HPRD   PubMed
 
  NP_004594.1   N ethylmaleimide sensitive factor   NSF     HPRD   PubMed
PS1 interacts with syntaxin 1A.
  NP_004594.1   NP_000012.1   PSEN1     BIND   PubMed
 
  NP_004594.1   RAB27A   RAB27A     HPRD   PubMed
 
  NP_004594.1   Sodium channel nonvoltage gated 1, beta   SCNN1B     HPRD   PubMed
 
  NP_004594.1   Sodium channel nonvoltage gated 1, gamma   SCNN1G     HPRD   PubMed
 
  NP_004594.1   NEDD5   SEPT2     HPRD   PubMed
 
  NP_004594.1   Septin 5   SEPT5     HPRD   PubMed
 
  NP_004594.1   Solute carrier family 6 (neurotransmitter transporter, GABA), member 1   SLC6A1     HPRD   PubMed
DAT interacts with Syn1A.
  NP_004594.1   NP_001035.1   SLC6A3     BIND   PubMed
 
  NP_004594.1   Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4   SLC6A4     HPRD   PubMed
 
  NP_004594.1   SLC6A9   SLC6A9     HPRD   PubMed
 
  NP_004594.1   NP_003816.2   SNAP23     HPRD   PubMed
 
  NP_004594.1   NP_003816.2   SNAP23     HPRD   PubMed
 
  NP_004594.1   Synaptosomal associated protein,25Kd   SNAP25     HPRD   PubMed
 
  NP_004594.1   Synaptosomal associated protein,25Kd   SNAP25     HPRD   PubMed
 
  NP_004594.1   NP_004773.1   SNAP29     HPRD   PubMed
 
  NP_004594.1   NP_004844.1   STX8     HPRD   PubMed
 
  NP_004594.1   Syntaxin binding protein 1   STXBP1     HPRD   PubMed
 
  NP_004594.1   Syntaxin binding protein 2   STXBP2     HPRD   PubMed
 
  NP_004594.1   Tomosyn   STXBP5     HPRD   PubMed
 
  NP_004594.1   AAM46624.1   STXBP6     HPRD   PubMed
 
  NP_004594.1   NP_005630.1   SYT1     HPRD   PubMed
 
  NP_004594.1   Synaptotagmin 4   SYT4     HPRD   PubMed
 
  NP_004594.1   NP_004191.2   SYT7     HPRD   PubMed
 
  NP_004594.1   Synaptotagmin like 4   SYTL4     HPRD   PubMed
 
  NP_004594.1   NP_694967.2   TXLNB     HPRD   PubMed
 
  NP_004594.1   MUNC13   UNC13B     HPRD   PubMed
 
  NP_004594.1   NP_005629.1   VAMP7     HPRD   PubMed
 
  NP_004594.1   Vesicle associated membrane protein 8   VAMP8     HPRD   PubMed
VPS11 interacts with STX1A (Syntaxin-1). This interaction was modeled on a demonstrated interaction between human VPS11 and STX1A (Syntaxin-1) from an unspecified species.
  NP_004594.1   NP_068375.3   VPS11     BIND   PubMed
VPS18 interacts with STX1A (Syntaxin-1). This interaction was modeled on a demonstrated interaction between human VPS18 and STX1A (Syntaxin-1) from an unspecified species.
  NP_004594.1   NP_065908.1   VPS18     BIND   PubMed
 
  NP_004594.1   Complexin 2       HPRD   PubMed
 
  NP_004594.1   ENaC protein       HPRD   PubMed
 
  NP_004594.1   GAT1       HPRD   PubMed
 
  NP_004594.1   H+ ATPase       HPRD   PubMed
 
  NP_004594.1   Munc18a       HPRD   PubMed
 
  NP_004594.1   Munc18b       HPRD   PubMed
 
  NP_004594.1   Syntaphilin       HPRD   PubMed
 
  NP_004594.1   Taxilin       HPRD   PubMed
 
  NP_004594.1   VAMP1       HPRD   PubMed
 
  NP_004594.1   VAMP2       HPRD   PubMed
 
  NP_004594.1   alpha-SNAP       HPRD   PubMed
G-beta1-gamma2 complex interacts with STX1A (syntaxin 1A). This interaction was modelled on a demonstrated interaction between G-beta1-gamma2 complex from an unspecified species and STX1A from an unspecified species.
  NP_004594.1         BIND   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:107008   ATP6V1B1     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:107455   CDK5     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112676   BioGRID:107506   CFTR     BioGRID   PubMed
Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
  BioGRID:112676   BioGRID:116028   CPLX1     BioGRID   PubMed
Affinity Capture-Western
  BioGRID:112676   BioGRID:116027   CPLX2     BioGRID   PubMed
Two-hybrid
  BioGRID:112676   BioGRID:119968   KIAA1128     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112676   BioGRID:114305   NAPA     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112676   BioGRID:115149   RNF40     BioGRID   PubMed
Affinity Capture-Western
  BioGRID:112676   BioGRID:112241   SCNN1A     BioGRID   PubMed
Affinity Capture-Western
  BioGRID:112676   BioGRID:112242   SCNN1B     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112676   BioGRID:112244   SCNN1G     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112676   BioGRID:112420   SLC6A1     BioGRID   PubMed
Affinity Capture-Western
  BioGRID:112676   BioGRID:112423   SLC6A4     BioGRID   PubMed
Affinity Capture-Western
  BioGRID:112676   BioGRID:114599   SLC6A5     BioGRID   PubMed
Affinity Capture-Western
  BioGRID:112676   BioGRID:112427   SLC6A9     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:112676   BioGRID:114303   SNAP23     BioGRID   PubMed
Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
  BioGRID:112676   BioGRID:112500   SNAP25     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:114748   SNAP29     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:112676   STX1A     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112676   BioGRID:112681   STXBP1     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:112682   STXBP2     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:126417   STXBP5     BioGRID   PubMed
Affinity Capture-Western
  BioGRID:112676   BioGRID:112721   SYP     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:112723   SYT1     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112676   BioGRID:125120   SYTL4     BioGRID   PubMed
Two-hybrid
  BioGRID:112676   BioGRID:203367   Snap23     BioGRID   PubMed
Two-hybrid
  BioGRID:112676   BioGRID:247095   Snap25     BioGRID   PubMed
Two-hybrid
  BioGRID:112676   BioGRID:108124   TRDMT1     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:128297   TXLNA     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:127952   TXLNB     BioGRID   PubMed
Co-fractionation; Two-hybrid
  BioGRID:112676   BioGRID:115759   UNC13B     BioGRID   PubMed
Two-hybrid
  BioGRID:112676   BioGRID:112710   VAMP1     BioGRID   PubMed
Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid
  BioGRID:112676   BioGRID:112711   VAMP2     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:112712   VAMP7     BioGRID   PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112676   BioGRID:114221   VAMP8     BioGRID   PubMed
Reconstituted Complex
  BioGRID:112676   BioGRID:114650   VAPB     BioGRID   PubMed
Two-hybrid
  BioGRID:112676   BioGRID:113272   VIM     BioGRID   PubMed

[Top][Help]General gene information

Markers

STX1A_264(e-PCR)
Links: UniSTS:277776
STS-L37792(e-PCR)
Links: UniSTS:18981
Alternate names: RH75865; sts-L37792
RH78389(e-PCR)
Links: UniSTS:6754
Alternate name: stSG41415
D7S2927(e-PCR)
Links: UniSTS:42596
Alternate names: GDB:739085; SHGC-16892
MARC_14487-14488:1010605685:1(e-PCR)
Links: UniSTS:267687
RH103672(e-PCR)
Links: UniSTS:97997
Alternate name: stSG62328

Homology

Mouse, Rat
Map Viewer

GeneOntology Provided by GOA

[Top][Help]General protein information

Preferred Names
syntaxin 1A (brain)
Names
syntaxin 1A (brain)

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_004603.2NP_004594.1 syntaxin 1A (brain)

    Source sequence(s)
    BC000444,BC064644
    Consensus CDS
    CCDS34655.1
    UniProtKB/Swiss-Prot
    Q16623
    UniProtKB/TrEMBL
    Q75ME0
    Conserved Domains (2) summary
    cd00179
    Location:30181
    Blast Score:380
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane...
    cd00193
    Location:195254
    Blast Score:139
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000007.13 Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

    Range
    73133988..73113540, complement
    Download
    GenBank  FASTA Sequence Viewer (Graphics)
  2. NT_007933.15

    Range
    11166831..11146383, complement
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (CRA_TCAGchr7v2)

Genomic

  1. AC_000068.1 Alternate assembly (CRA_TCAGchr7v2)

    Range
    72467060..72446612, complement
    Download
    GenBank  FASTA Sequence Viewer (Graphics)
  2. NT_079593.2

    Range
    11162308..11141860, complement
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000050.1 Alternate assembly (Celera)

    Range
    68612194..68591744, complement
    Download
    GenBank  FASTA Sequence Viewer (Graphics)
  2. NW_923450.1

    Range
    419088..398638, complement
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000139.1 Alternate assembly (HuRef)

    Range
    68995956..69016404
    Download
    GenBank  FASTA Sequence Viewer (Graphics)
  2. NW_001839039.2

    Range
    1038160..1058608
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

Nucleotide   Protein
Genomic   AC073846.6   AAS07469.1
    AAS07470.1
Genomic   CH471200.2   EAW69649.1
    EAW69650.1
    EAW69651.1
    EAW69652.1
    EAW69653.1
    EAW69654.1
    EAW69655.1
Genomic   U87315.1   AAB65500.2
    AAK54507.2
mRNA   AB086954.1   BAC78519.1
mRNA   AK299959.1   BAG61785.1
mRNA   AK313980.1   BAG36694.1
mRNA   BC000444.2    None
mRNA   BC003011.1   AAH03011.1
mRNA   BC064644.1   AAH64644.1
mRNA   CR457018.1   CAG33299.1
mRNA   CR601836.1    None
mRNA   CR621226.1    None
mRNA   D37932.1   BAA07151.1
mRNA   L37792.1   AAA53519.1
mRNA   U12918.1   AAA20940.1
Protein Accession   Links
Q16623.1   GenPept   UniProtKB/Swiss-Prot
Q75ME0   GenPept   UniProtKB/TrEMBL
Q7Z5K3   GenPept   UniProtKB/TrEMBL